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KMID : 1123920120260050732
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Korean Journal of Oriental Physiology and Pathology
2012 Volume.26 No. 5 p.732 ~ p.737
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Effects of Sokmyong-tang on Ferric Chloride-induced Carotid Injury and Thrombosis in a Rat Model
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Heo Eun-Jung
Lee In-Sun
Kang Hyung-Won
Jeon Won-Kyung
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Abstract
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The aim of this study is examine the protection effect for artery and antithrombotic effect of Sokmyong-tang(SMT; xuming-tang) on carotid artery thrombosis in a rat model. Thirty minutes before Fecl3 treatment, SD rats were intraperitoneal injected with SMT. We tested the effects of SMT on time to occlusion (TTO) in thrombosis model by induced Fecl3 using the laser Doppler flow meter and accessed thrombus weight (TW) inhibition and measured collagen fibers in the vessel after injury using Masson’s trichrome stain. SMT(100 mg/kg, i.p.) showed significantly delayed TTO (13.17±1.33 min,P<
0.001)compared to vehicle control group(8.63±0.92 min)and inhibiting effect on TW with 0.72±0.02 mg/mm (P < 0.05). In addition, SMT prevented collagen fibres damage in injured vessel (22.24±4.48, P < 0.001). These results provide experimental evidence for SMT can be used to prevent vascular injury and thrombosis such as hypertension, arteriosclerosis, and so on.
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KEYWORD
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sokmyong-tang, herbal medicine, carotid artery thrombosis model, thrombosis, vascular injury
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